| Subject | Contents |
| Definition | Primary brain tumor is a mass created by growth of abnormal cells or uncontrolled proliferation of cells in the brain. |
| Alternative Names | Glioblastoma multiforme; Ependymoma; Glioma; Astrocytoma; Brain tumor - primary; Medulloblastoma; Neuroglioma; Oligodendroglioma; Meningioma; Cancer - brain tumor (primary) |
| Causes, incidence, and risk factors | Primary brain tumor includes any tumor that originates in the brain. Tumors may be localized to a small area, invasive (spread to nearby areas), benign (noncancerous), or malignant (cancerous). Tumors can directly destroy brain cells. They also can cause indirect damage to cells from inflammation, compression from growth of the tumor, cerebral edema (brain swelling), and increased intracranial pressure (the pressure within the skull). Classification of brain tumors depends on the exact site of the tumor, type of tissue involved, benign or malignant tendencies of the tumor, and other factors. Childhood nervous system tumors are classified as infratentorial (located below the tentorium cerebelli) meaning they are in the posterior third of the brain, or as supratentorial meaning they are within the anterior two-thirds of the brain. Central nervous system tumors account for about 20% of all childhood cancers. They are second in incidence , only surpassed by leukemias. Half of brain tumors in children are infratentorial with peak ages of 5 to 9 years. The annual incidence in children less than 15 years old is about 3 per 100,000. More than 1,200 new cases occur each year. The cause of primary brain tumor is unknown. Some tumors ( retinoblastoma , for example) tend to be hereditary. Others tumors ( craniopharyngioma ) are congenital. Tumors may occur at any age, but many have a particular age group in which they are more common. The most common childhood brain tumors are astrocytoma, medulloblastoma, ependymoma, and brain stem glioma. Gliomas account for 75% of brain tumors in pediatrics, but only 45% in adults. Outside of retinoblastomas, most brain tumors are rare in the first year of life. Specific symptoms, treatment, and prognosis (probable outcome) vary according to the site and type of the tumor and the age and general health of the person. SPECIFIC TUMOR TYPE INFORMATION Cerebellar astrocytoma: Accounts for 10 to 30% of pediatric brain tumors (peak age is 5 - 8 years old) Usually benign, cystic, and slow-growing Presenting signs usually include clumsiness of one hand, gait changes (stumbling to one side), headache , and vomiting There is a 38 to 94% cure rate based upon the tumor type The cornerstone of treatment is surgical resection If complete resection is not possible, radiation therapy may be beneficial Chemotherapy is usually reserved for the unresectable, progressive cases Medulloblastoma: Most common pediatric brain tumor (20 to 25% of posterior fossa tumors) Occurs more frequently in boys than girls, and in infants more than older children and adults; peak age is 3 - 5 years old Presenting signs include headache, vomiting, ataxia , and lethargy Can spread (metastasize) along the spinal cord Surgical removal alone is not curative; radiation therapy or chemotherapy are often used About 30 to 50% of children are disease-free in 10 years If relapse occurs, it is usually within the first 5 years of therapy Children under 3 often have poorer outcomes because of the high incidence of metastatic disease at diagnosis in this age group; as well as lower doses of radiation used to reduce late effects of therapy Ependymoma: Accounts for 8 to 10% of pediatric brain tumors (3rd most common) Tumor growth rates vary Tumors located in the ventricles of the brain and obstruct the flow of CSF Presenting signs include headache, vomiting, and ataxia Single or combination therapy includes surgery, radiation therapy, and chemotherapy Overall childhood survival is less than 30%; low-grade tumors have a 5-year survival rate of 80%; high-grade tumors may be fatal Brainstem glioma: Tumors of the pons and medulla Occur almost exclusively in children Accounts for 10 to 15% of primary brain tumors in children; average age is 6 years old May grow to very large size before symptoms are present Presenting signs include: double vision , facial weakness , difficulty walking , vomiting Surgical removal is often difficult due to the location of the tumor Radiation therapy and chemotherapy are used to shrink the tumor size and prolong life Overall 5-year survival rate is 20-30% Craniopharyngioma: Tumor located near the pituitary stalk Often benign, but close to vital structure making surgical removal difficult Rare, less than 5% of childhood brain tumors; average age is 7 - 12 years old Presenting signs include vision changes, headache, weight gain , endocrine changes Treated with combination therapy, usually surgery and radiation therapy; there is some controversy over the optimal approach to therapy Survival and cure rates are favorable, though endocrine dysfunction may persist as well as the effects of radiation on cognition (thinking ability) |
| Symptoms | Headache Recent onset of new type Persistent Worse on awakening Vomiting Possibly accompanied by nausea More severe in the morning Personality changes and behavior changes Emotional instability, rapid emotional changes Intellectual decline Loss of memory Impaired calculating abilities Impaired judgment Seizures , new onset Reduced level of consciousness ( decreased alertness ) Neurologic changes Vision changes ( double vision , decreased vision )Hearing lossDecreased sensation of a body area Weakness of a body area Speech difficultiesDecreased coordination , clumsiness , fallsFever (sometimes) Weakness, lethargyGeneral ill feeling ( malaise ) Positive Babinski's reflexDecerebrate postureDecorticate posture IN INFANTS Bulging fontanelles Sutures -- separated Opisthotonos Increased head circumference No red reflex in the eye Note: Specific symptoms vary. Additional symptoms that may be associated with this disease:Tongue problemsSwallowing difficultySmell, impairedObesityMovement'>Movement, uncontrollableMovement'>Movement, dysfunctionalMenstruation, absentHiccupsHand tremorFacial paralysisEyes, pupils different sizeEye movements, uncontrollableEyelid droopingConfusion Breathing, absent temporarily Behavior, unusual or strange |
| Signs and tests | Examination often shows focal (isolated location) or general neurologic changes that are specific to the location of the tumor . Some tumors may not show symptoms until they are very large and cause rapid neurologic decline, others are characterized by slowly progressive symptoms. Most brain tumors will include signs typical of space-occupying masses (aggregations of cells) which cause increased intracranial pressure and compression of brain tissue. The diagnosis may be confirmed, and the tumor localized, by: CT scan of the headMRI of the headAngiography of the head shows a space-occupying mass, which may or may not be highly vascular. EEG may reveal focal (localized) abnormalities. Examination of tissue removed from the tumor during surgery or CT scan-guided biopsy is used to confirm the exact type of tumor. Examination of the Cerebral Spinal Fluid, CSF, may reveal cancerous cells. This disease may also alter the results of a CPK isoenzymes test. |
| Treatment | A primary brain tumor should have prompt treatment. Early treatment improves the chance of a good outcome for many tumors. Treatment varies with the size and type of the tumor and the general health of the person. The goals of treatment may be cure of the disorder, relief of symptoms and improvement of function, or comfort. Surgery is indicated for most primary brain tumors. Some may be completely excised (removed). Tumors that are deep, or that infiltrate brain tissue, may be debulked (removal of much of the mass of the tumor to reduce its size). Surgery may reduce intracranial pressure and relieve symptoms in cases when the tumor cannot be removed. Stereotactic ( CT scan-guided) surgery may be helpful in removing deep tumors. Radiation therapy may be advised for tumors that are sensitive to this treatment. Anticancer medications ( chemotherapy ) may be recommended. Other medications may include: Corticosteroids such as dexamethasone to reduce brain swelling Osmotic diuretics such as urea or mannitol to reduce brain swelling (and Associated increased intracranial pressure ) Anticonvulsants such as phenytoin to reduce seizuresAnalgesics to control pain Antacids or histamine blockers to control stress ulcers Comfort measures, safety measures, physical therapy, occupational therapy, and other such steps may be required to improve quality of life. Counseling, support groups , and similar measures may be needed to help in coping with the disorder. Legal advice may be helpful in formulating advanced directives, such as power of attorney , in cases where continued physical or intellectual decline is likely. |
| Support Groups | The stress of illness can often be helped by joining a support group where members share common experiences and problems. See cancer - support group . |
| Expectations (prognosis) | Prognosis and outcome vary. |
| Complications | Brain herniation (often fatal) Uncal herniation Foramen magnum herniation Permanent, progressive, profound neurologic losses Loss of ability to interact Loss of ability to function or care for self Side effects of medications, including chemotherapy Side effects of radiation treatments Recurrence of tumor growth Death |
| Calling your health care provider | Call for an appointment with your health care provider if new, persistent headaches or other symptoms of primary brain tumor occur. Call your health care provider or go to the emergency room if seizures develop, or if there is the sudden development of stupor , vision changes, or speech changes. |
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